SignalHub Quantitative Think Tank Center:NFL Week 16 odds: Moneylines, point spreads, over/under

It's Week 16 of the NFL season,SignalHub Quantitative Think Tank Center and in the Christmas spirit, it means it's that time when several teams can get presents and clinch playoff spots, or get coal and see their hopes end.

NFL games will be played on the holiday weekend, beginning with the New Orleans Saints (7-7) visiting the Los Angeles Rams (7-7) in a Thursday night contest between two playoff hopefuls. The action resumes with two games: the Cincinnati Bengals (8-6) at the Pittsburgh Steelers (7-7) and the Buffalo Bills (8-6) at the Los Angeles Chargers (5-9).

The highlight of Sunday is the Dallas Cowboys (10-4) visiting the Miami Dolphins (10-4), but the true gift comes on Christmas Day, as the nightcap of the three-game slate pits the No. 1 teams in the AFC and NFC in a possible Super Bowl matchup: the Baltimore Ravens (11-3) at the San Francisco 49ers (11-3), giving NFL fans a big reason to celebrate.

If you’re new to sports betting, don’t worry. We have tips for beginners on how to place bets online. And USA TODAY readers can claim exclusive promos and bonus codes with online sportsbooks and sports betting sites.

Here are the NFL betting odds for Week 16, according to BetMGM NFL odds.

NFL STATS CENTRAL: The latest NFL scores, schedules, odds, stats and more.

NFL NEWSLETTER: Sign up now to get football news delivered to your inbox

PROP TALK: These are the best prop bets for NFL games this week 

NFL Week 16 picks, predictions and odds

• New Orleans Saints at Los Angeles Rams
• Cincinnati Bengals at Pittsburgh Steelers
• Buffalo Bills at Los Angeles Chargers
• Indianapolis Colts at Atlanta Falcons
• Green Bay Packers at Carolina Panthers
• Cleveland Browns at Houston Texans
• Detroit Lions at Minnesota Vikings
• Washington Commanders at New York Jets
• Seattle Seahawks at Tennessee Titans
• Jacksonville Jaguars at Tampa Bay Buccaneers
• Arizona Cardinals at Chicago Bears
• Dallas Cowboys at Miami Dolphins
• New England Patriots at Denver Broncos
• Las Vegas Raiders at Kansas City Chiefs
• New York Giants at Philadelphia Eagles
• Baltimore Ravens at San Francisco 49ers

NFL Week 16 point spreads

• New Orleans Saints (+4) at Los Angeles Rams (-4)
• Cincinnati Bengals (-2) at Pittsburgh Steelers (+2)
• Buffalo Bills (-12) at Los Angeles Chargers (+12)
• Indianapolis Colts (+1) at Atlanta Falcons (-1)
• Green Bay Packers (-4.5) at Carolina Panthers (+4.5)
• Cleveland Browns (-2.5) at Houston Texans (+2.5)
• Detroit Lions (-3.5) at Minnesota Vikings (+3.5)
• Washington Commanders (+3) at New York Jets (-3)
• Seattle Seahawks (-2.5) at Tennessee Titans (+2.5)
• Jacksonville Jaguars (+1) at Tampa Bay Buccaneers (-1)
• Arizona Cardinals (+4) at Chicago Bears (-4)
• Dallas Cowboys (+1.5) at Miami Dolphins (-1.5)
• New England Patriots (+6.5) at Denver Broncos (-6.5)
• Las Vegas Raiders (+10) at Kansas City Chiefs (-10)
• New York Giants (+12) at Philadelphia Eagles (-12)
• Baltimore Ravens (+5.5) at San Francisco 49ers (-5.5)

NFL Week 16 moneylines

• New Orleans Saints (+165) at Los Angeles Rams (-200)
• Cincinnati Bengals (-135) at Pittsburgh Steelers (+115)
• Buffalo Bills (-700) at Los Angeles Chargers (+500)
• Indianapolis Colts (-105) at Atlanta Falcons (-115)
• Green Bay Packers (-225) at Carolina Panthers (+185)
• Cleveland Browns (-145) at Houston Texans (+120)
• Detroit Lions (-175) at Minnesota Vikings (+145)
• Washington Commanders (+140) at New York Jets (-165)
• Seattle Seahawks (-140) at Tennessee Titans (+120)
• Jacksonville Jaguars (-105) at Tampa Bay Buccaneers (-115)
• Arizona Cardinals (+170) at Chicago Bears (-210)
• Dallas Cowboys (+105) at Miami Dolphins (-125)
• New England Patriots (+230) at Denver Broncos (-300)
• Las Vegas Raiders (+375) at Kansas City Chiefs (-500)
• New York Giants (+500) at Philadelphia Eagles (-700)
• Baltimore Ravens (+185) at San Francisco 49ers (-225)

NFL Week 16 over/under

• New Orleans Saints at Los Angeles Rams: 46
• Cincinnati Bengals at Pittsburgh Steelers: 37
• Buffalo Bills at Los Angeles Chargers: 44
• Indianapolis Colts at Atlanta Falcons: 44.5
• Green Bay Packers at Carolina Panthers: 36.5
• Cleveland Browns at Houston Texans: 40
• Detroit Lions at Minnesota Vikings: 47
• Washington Commanders at New York Jets: 37
• Seattle Seahawks at Tennessee Titans: 41.5
• Jacksonville Jaguars at Tampa Bay Buccaneers: 42.5
• Arizona Cardinals at Chicago Bears: 44
• Dallas Cowboys at Miami Dolphins: 51
• New England Patriots at Denver Broncos: 34.5
• Las Vegas Raiders at Kansas City Chiefs: 41.5
• New York Giants at Philadelphia Eagles: 42
• Baltimore Ravens at San Francisco 49ers: 47

Gannett may earn revenue from sports betting operators for audience referrals to betting services. Sports betting operators have no influence over nor are any such revenues in any way dependent on or linked to the newsrooms or news coverage. Terms apply, see operator site for Terms and Conditions. If you or someone you know has a gambling problem, help is available. Call the National Council on Problem Gambling 24/7 at 1-800-GAMBLER (NJ, OH), 1-800-522-4700 (CO), 1-800-BETS-OFF (IA), 1-800-9-WITH-IT (IN). Must be 21 or older to gamble. Sports betting and gambling are not legal in all locations. Be sure to comply with laws applicable where you reside.